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Gaurav Aman Luther, M.D.

Gaurav Aman Luther, M.D. Board Certified in Orthopedic Surgery and Hand and Upper Extremity Surgery

Dr. Luther is a board-certified, fellowship trained Hand and Upper Extremity Surgeon. He earned his BS from the Massachusetts Institute of Technology (MIT) and MD degree from the University of Chicago. He completed his orthopedic surgery residency at Harvard Medical School- training at Massachusetts General Hospital, Brigham & Women's Hospital, Boston Children's Hospital and Beth Israel Deaconess Medical Center. He was a chief resident at Massachusetts General Hospital then went on to pursue a subspecialty fellowship in hand and upper extremity surgery at the Harvard Hand Fellowship in Boston.

Over his career Dr. Luther has published over 20 peer-reviewed papers, several book chapters, and lectured nationally and internationally on hand and upper extremity disorders.  He is the recipient of numerous research and teaching awards and an active member of the American Academy of Orthopaedic Surgeons (AAOS) and American Society for Surgery of the Hand (ASSH). He currently serves on national committees focused on medical education and value-based healthcare delivery. Throughout his career, he has focused on delivering exceptional patient care by combining his interests in education, research and clinical care.

Dr. Luther has a clinical interest in nerve injuries and reconstruction, peripheral nerve surgery, hand and upper extremity fractures, minimally invasive surgery, ligament and tendon disorders, rheumatoid and osteoarthritis, joint replacement, and pediatric hand surgery.  As a collegiate tennis player, Dr. Luther also enjoys caring for athletes with hand and upper extremity injuries, with a focus on early return to play.

His outside interests include value-based healthcare delivery, medical education, health care efficiency and patient-centered quality and outcomes research. In his free time, he enjoys playing tennis, soccer, hiking and traveling the world. He has moved to North Carolina from Boston with his wife, kids and dog and enjoy exploring all that the area has to offer.

Click here to download Dr. Luther CV

 

Dr. Luther discusses the Causes & Treatment Options for Arthritis

Hand and wrist arthritis are common conditions that can cause pain, swelling and loss of function in the hand. A variety of treatments exist to help patients alleviate pain and return to activities they desire.

 

Education

  • Sep 2007 - June 2012
    University of Chicago: Pritzker School of Medicine, MD
    Graduated with Honors
  • Aug 2003 - Jun 2001
    Massachusetts Institute of Technology
    Bachelor of Science in Biology

Postgraduate Training

  • Jun 2012 - June 2017
    Harvard Combined Orthopaedics Residency Program
    MGH Chief Resident
  • Jan 2017
    Harvard Business School
    Value Based Health Care Certification with Michael Porter and Robert Kaplan
  • Jun 2017 - Jun 2018
    Harvard Hand/Upper Extremity Fellowship-Brigham and Women's Hospital

Honors & Awards

  • Jun 2017
    Best Clinical Research Award - Harvard Combined Orthopaedics Residency
  • Jun 2016
    Chief Resident - Massachusetts General Hospital/Harvard Combined Orthopaedics Residency
  • Sep 2015
    Clinician Scholar Development Program - America Academy of Orthopaedic Surgeons
  • May 2015
    Resident Teaching Award - Harvard Medical School
  • Mar 2014
    Best Poster Award - Adult Hip Reconstruction, American Academy of Orthopedic Surgeons Conference
  • Oct 2013
    Adrian E. Flatt Resident Research Scholarship - American Society of Surgery for the Hand
  • May 2012
    Leon Jacobson Award for Best Oral Presentation - Senior Scientific Session, University of Chicago Pritzker School of Medicine
  • Apr 2012
    Best Abstract - International Congress for Joint Reconstruction Conference
  • Feb 2012
    Best Oral Presentation - Tumor Society, American Academy of Orthopedic Surgeons
  • Aug 2011
    Fentress Research Fellowship - University of Chicago Pritzker School of Medicine
  • Mar 2011
    Best Basic Science Presentation - Huggins Research Symposium, University of Chicago Pritzker School of Medicine
  • Mar 2011
    Best Clinical Presentation - Huggins Research Symposium, University of Chicago Pritzker School of Medicine
  • Jun 2010
    Pritzker Research Fellowship - University of Chicago Pritzker School of Medicine

Peer-Reviewed Publications (Primary Authorship)

  • Luther G., Blazar P., Dyer G. Achieving Microsurgical Competency in Orthopedic Residents utilizing a Self-Directed Microvascular Training Curriculum. Journal of Bone and Joint Surgery. Feb 2019.PMID: 30730490
  • Luther G., Murthy, P., Blazar P. Cost of immediate surgery versus non-operative treatment for trigger finger in diabetic patients. Journal of Hand Surgery. Sep 2016. PMID: 27671766
  • Luther G., Miller P., Mahan S., Waters PM., Bae DS. Decreasing resource utilization using standardized clinical assessment and management plans (SCAMPs). J Pediatric Orthopaedics. Sep 2016. PMID: 27636917
  • Luther G, Miller P, Waters PM, Bae DS. Radiographic evaluation of pediatric forearm fractures: implications on cost and care. J Pediatric Orthopaedics. Apr 2015. PMID: 25887819
  • Luther G., Lamplot J., Chen X., Rames R., Wagner E., Shen J., Haydon R., He T.C., Luu H. IGFBP5 Domains Exert Distinct Inhibitory Effects on the Tumorigenicity and Metastasis of Human Osteosarcoma. Cancer Letters. May 2013. PMID 23665505
  • Luther G., Wagner E., Zhu G., Kang Q., Luo Q., Lamplot J., Bi Y., Luo X., Luo J., Teven C., Shi Q., Kim S., Gao J., Huang E., Rames R., Liu X., Li M., Hu N., Su Y., Chen L., He B.C., Zuo G., Deng Z., ReidR., Luu H., Haydon R., He T.C. BMP-9 Induced Osteogenic Differentiation of MesenchymalStem Cells: Molecular Mechanism and Therapeutic Potential. Current Gene Therapy. March 2011.PMID 21453282
  • Luther G., RamesR., Wagner E., Zhu G., Luo Q., Bi Y., Kim S., Gao J., Huang E., Yang K., Wang L., Liu X., Li M., Hu N., Su Y., Luo X., Chen L., Luo J., Haydon R., Luu H., Zhou L., He T.C. Molecular Basis of Differentiation Therapy for Soft Tissue Sarcomas. Trends in Cancer Research. Jan 2011.

Peer-Reviewed Publications (Other)

  • Ordikhani F., Zandi N., Mazaheri M., Luther G., Ghovvatoi M., Akbarzadeh A., Annabi N. Targeted Nanomedicines for the treatment of bone disease and regeneration. Medicinal Research Reviews. Dec 2020
  • Behzadi S., Luther G., Harris MB., Farokhzad O., Mahmoudi M. Nanomedicine for safe healing of bone trauma: Opportunities and challenges. Biomaterials. Sep 2017.
  • Lamplot J, Luther G, Mawdsley EL, Luu HH, ManningD. Modified Protocol Decreases Surgical Site Infections after Total Knee Arthroplasty. Journal of Knee Surgery. Mar 2015. PMID 25699629
  • Lamplot J., Liu B., Zhang W., Wang Z., Luther G., Wagner E., He T.C., Ho S. Reversibly immortalized articular chondrocytes acquire long-term proliferative capability while retaining chondrogenic phenotype. Cell Transplantation. Apr 2014.PMID 24800751
  • Chen X., Luther G., Zhang W., Nan G., Wagner E., Liao Z., Haydon R., Zhou L., Luu H., He T.C. The E-F hand calcium-binding protein S100A4 regulates the proliferation, survival and differentiation potential of humanosteosarcoma cells. Cellular Physiology and Biochemistry. Sep 2013.PMID 24217649
  • Hekman K., Aliaga L., Straus D., Luther G., Chen J., Sampat., Frim D. Positive and negative predictors for good outcome after decompressive surgery for Chiari malformation type 1 as scored on the Chicago Chiari Outcome Scale. Neurological Research. Sep 2012. PMID 22781921
  • Aliaga L., Yassari R., Straus D., Hekman K., Luther G., Chen J., Sampat A., Frim D. A Novel Scoring System for Assessing Chiari Malformation Type 1 Treatment Outcomes. Neurosurgery. Mar 2012.PMID 21849925
  • Teven C., Liu X., Hu N., Tang N., Kim S., Huang E., Yang K., Li M., Gao J., Liu H., Luther G., Luo Q., Wang L., Rames R., Bi Y., Luo J., Luu H., Haydon R., Reid R., He T.C. Epigentic regulation of mesenchymal stem cells: A focus on osteogenic and adipogenic differentiation. Stem Cells and Nuclear Reprogramming. Jul 2011. PMID 21772852
  • Wagner E. Luther G., , Zhu G., Luo Q., Shi Q., Kim S., Gao J., Huang E., Gao Y., Yang K., Wang L., Teven C., Luo X., Liu X., Li M., Hu N., Su Y., Bi Y., He B.C., Haydon R., Luu H., He T.C. Defective Osteogenic differentiation in the development of osteosarcoma. Sarcoma. Feb 2011. PMID 21437219
  • Pandey S., Luther G., Umanskiy K., Malhotra G., Rubin M., Hurst R., Fichera A. Minimally invasive pouch surgery for ulcerative colitis. Is there a benefit in staging? Diseases of the Colon and Rectum. Feb 2011. PMID 21304301
  • Rastegar F., Gao J., Shenaq D., Luo Q., Shi Q., Kim S., Jiang W., Wagner E., Huang E., Gao Y., Shen J., Yang K., He B.C., Chen L., Zuo G., Luo J., Luo X., Bi Y., Liu X., Li M., Hu N., Wang L., Luther G., Luu H., Haydon R., He T.C. Lysophosphatidic acid acyltransferase b (LPAATb) promotes tumor growth of human osteosarcoma. PLoS ONE. Dec 2010. PMID 21152068
  • He B.C., Gao J., Zhang B., Luo Q., Shi Q., Kim S., Huang E., Gao Y., Yang K., Wagner E., Wang L., Tang N., Luo J., Liu X., Li M., Bi., Shen J., Luther G., Hu N., Zhou Q., Luu H., Haydon R., Zhao Y., He T.C. Tetrandrine Inhibits Wnt/ β-Catenin Signaling and Suppresses Tumor Growth of Human Colorectal Cancer. Molecular Pharmacology. Oct 2010.PMID 20978119
  • Teply B., Tong R., JeongS., Luther G., Sherifi I., Yim C., Khademhosseini A., Farokhzad O., Langer R., Cheng J. The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules. Biomaterials. Dec 2007. PMID18082254
  • Cheng J., Teply B., Sherifi I., Sung J., Luther G., Gu F., Nissenbaum E., Moreno A., Langer R., Farokhzad O. Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials. Feb 2007. PMID 17055572

Podium Presentations (in chronological order)

  • Luther G, Blazar P, Dyer, G. Effectiveness of a microvascular training curriculum utilizing nonliving models. Richard J. Smith Annual Research Symposium. April 2017.
  • Luther G, Miller P, Mahan, S, Waters PM, Bae DS. Decreasing resource utilization using standardized clinical assessment and management plans (SCAMPs). RichardJ. Smith Annual Research Symposium. May 2014.
  • Lamplot J., Luther G., Luu H., Manning D. Aseptic protocol decreases surgical site infections following hip arthroplasty. Mid-America Orthopaedic Association Annual Meeting. Apr 2014.
  • Lamplot J., Luther G., Krummenacher T., Hussain M., Luu H., Manning D. Aseptic protocol decreases surgical site infection after knee arthroplasty. American Academy of Orthopaedic Surgeons (AAOS) Annual Conference. Mar 2014.
  • Luther G, Miller P, Waters PM, Bae DS. Radiographic evaluation of pediatric forearm fractures: implications on cost and care. American Academy of Orthopaedic Surgeons (AAOS) Annual Conference. Mar 2014.
  • Luther G, Miller P, Waters PM, Bae DS. Radiographic evaluation of pediatric forearm fractures: implications on cost and care. Richard J. Smith Annual Research Symposium. May 2013.
  • Luther G, Stack M, Manning D. A novel aseptic protocol decreases surgical site infections following total hip and revision hip arthroplasty. International Congress for Joint Reconstruction (Apr 2012), MidAmerica Orthopaedics Association Annual Meeting(Apr 2012)
  • Luther G, Wagner E, Rames R., Lamplot J., Haydon R, He T.C., Luu H. Functional characterization of IGFBP-5 in the inhibition of osteosarcoma tumorigenicity. American Academy of Orthopaedic Surgeons (AAOS) Annual Conference-Tumor Society Best Oral Presentation. Feb 2012.
  • Luther G., Rames R., Wagner E., Lamplot J., Haydon R., He T.C., Luu H. Mechanism of Osteosarcoma tumorigenesis by S100A4. American Academy of Orthopaedic Surgeons (AAOS) Annual Conference. Feb 2012.
  • Luther G, Rames R, Wagner E, Haydon R, He T.C., Luu H. Functional characterization of IGFBP-5 in the inhibition of osteosarcoma tumorigenicity. Huggins Research Symposium: Winner of Best Basic SciencePresentation. Apr 2011.
  • Rames R, Luther G, Lamplot J, Wagner E, Luu H, He T.C. Induction of chondrogenic differentiation in Mesenchymal Stem Cells using a novel combination of Sox Transcription Factors and Bone Morphogenetic Proteins. Huggins Research Symposium: Winner of Best Clinical Presentation. Apr 2011.
  • Wagner E., Luther G., Haydon R., He T.C., Luu H. The mechanism underlying the inhibition of osteosarcoma tumorgenecity by IGFBP5. American Academy of Orthopaedic Surgeons (AAOS)Annual Conference. Feb 2011.

Poster Presentations (in chronological order)

  • Luther G., Blazar P., Dyer G. Development of a low-cost, high-fidelity resident microsurgical training curriculum. American Society for Surgery of the Hand(ASSH) Annual Conference. Oct 2017.
  • Luther G., Murthy, P., Blazar P. Cost of immediate surgery versus non-operative treatment for trigger finger in diabetic patients. American Society for Surgery of the Hand(ASSH) Annual Conference. Oct 2016
  • Luther G, Miller P, Mahan, S, Waters PM, Bae DS. Decreasing resource utilization using standardized clinical assessment and management plans (SCAMPs). American Academy of Orthopaedic Surgeons (AAOS) Annual Conference. Mar 2015.
  • Lamplot J., Luther G., Borque K., Luu H.H., Manning D.W. Aseptic protocol decreases surgical site infection after hip arthroplasty. American Academy of Orthopaedic Surgeons (AAOS) Annual Conference. Mar 2014.
  • Luther G, Miller P, Waters PM, Bae DS. Radiographic evaluation of pediatric forearm fractures: implications on cost and care. Society for Surgery of the Hand(ASSH) Annual Conference. Oct 2013.
  • Lamplot J., Luther G., He T.C., Luu H. Methylation of IGFBP5 promoter regulates human osteosarcoma. Orthopaedic Research Society (ORS) Annual Conference. Jan 2013.
  • Luther G, Stack M, Rames R, Manning D. A novel aseptic protocol decreases surgical site infections following total hip and revision hip arthroplasty. International Congress of Joint Reconstruction. Apr 2012.
  • Luther G., Rames R., Wagner E., Haydon R., He T.C., Luu H. Inhibition of Osteosarcoma metastasis byInsulin Growth Factor Binding Protein 5 (IGFBP5). Orthopaedic Research Society (ORS) Annual Conference. Feb 2012.
  • Luther G., Rames R., Wagner E., Haydon R., He T.C., Luu H. Mechanism of Osteosarcoma tumorigenesis by S100A4. Orthopaedic Research Society (ORS) Annual Conference. Feb 2012.
  • Luther G, Rames R, Wagner E, Haydon R, He T.C., Luu H. Functional characterization of IGFBP-5 in the inhibition of osteosarcoma tumorigenicity. American Society of Clinical Oncology (ASCO) Annual Conference. Jun 2011.
  • Luther G, Stack M, Manning D. Use of trabecular metal components in revision hip arthroplasty. Huggins Annual Research Symposium. Apr 2011.
  • Luther G, Stack M, Rames R, Manning D. Surgical site infections following total hip and revision hip arthroplasty. Huggins Annual Research Symposium. Apr 2011.
  • Luther G, Wagner E, Rames R, Haydon R, He T.C., Luu H. S100A6 is a novel inducer of osteosarcoma tumorigenicity. Huggins Annual Research Symposium. Apr 2011.
  • Luther G, Rames R, Wagner E, Haydon R, He T.C., Luu H. Functional characterization of IGFBP-5 in the inhibition of osteosarcoma tumorigenicity. Huggins Annual Research Symposium. Apr 2011.
  • Rames R, Luther G, Lamplot J, Wagner E, Luu H, He T.C. Establishment and characterization of a novel murine chondrocytic cell line. Huggins Annual Research Symposium. Apr 2011.
  • Rames R, Luther G, Lamplot J, Wagner E, Luu H, He T.C. Induction of chondrogenic differentiation in Mesenchymal Stem Cells using a novel combination of Sox Transcription Factors and Bone Morphogenetic Proteins. Huggins Annual Research Symposium. Apr 2011.
  • Luther G., Wagner E., Haydon R., He T.C., Luu H. Delineating the Role of S100A6 in Osteosarcoma and Osteogenic Differentiation. Orthopaedic Research Society (ORS) Annual Conference. Jan 2011.
  • Luther G., Wagner E., Haydon R., He T.C., Luu H. The Mechanism Underlying the Inhibition of Osteosarcoma Tumorigenicity by IGFBP5. Orthopaedic Research Society (ORS) Annual Conference. Jan 2011.

Memberships & Publications

  • Luther G., Blazar P., Dyer G. Achieving Microsurgical Competency in Orthopedic Residents Utilizing a Self-Directed Microvascular Training Curriculum.Accepted to JBJS. Mar 2018
  • Luther G., Murthy P., Blazar P. Cost of Immediate Surgery Versus Non-Operative Treatment for Trigger Finger in Diabetic Patients.Journal of Hand Surgery. Sep 2016. PMID: 27671766
  • Luther G., Miller P., Mahan S., Waters PM., Bae DS. Decreasing Resource Utilization Using Standardized Clinical Assessment and Management Plans (SCAMPs).J Pediatric Orthopaedics. Sep 2016. PMID: 25887819
  • Luther G., Lamplot J., Chen X., Rames R., Wagner E., Shen J., Haydon R., He T.C., Luu H., IGFBP5 Domains Exert Distinct Inhibitory Effects on the Tumorigenicity and Metastasis of Human Osteosarcoma. Cancer Letters. May 2013 PMID: 23665505
  • Luther G., Wagner E., Zhu G., Kang Q., Luo Q., Lamplot J., Bi Y., Luo X., Luo J., Teven C., Shi Q., Kim S., Gao J., Huang E., Rames R., Liu X., Li M., Hu N., Su Y., Chen L., He B.C., Zuo G., Deng Z., Reid R., Luu H., Haydon R., He T.C. BMP-9 Induced Osteogenic Differentiation of Mesenchymal Stem Cells: Molecular Mechanism and Therapeutic Potential. Current Gene Therapy. Mar 2011. PMID: 21453282
  • Luther G., Rames R., Wagner E., Zhu G., Luo Q., Bi Y., Kim S., Gao J., Huang E., Yang K., Wang L., Liu X., Li M., Hu N., Su Y., Luo X., Chen L., Luo J., Haydon R., Luu H., Zhou L., He T.C. Molecular Basis of Differentiation Therapy for Soft Tissue Sarcomas.Trends in Cancer Research. Jan 2011
  • Behzadi S., Luther G., Harris MB., Farokhzad O., Mahmoudi M., Nanomedicine for Safe Healing of Bone Trauma: Opportunities and Challenges. Biomaterials. Sep 2017
  • Lamplot J., Luther G., Mawdsley E.L., Luu H.H., Manning D. Modified Protocol Decreases Surgical Site Infections after Total Knee Arthroplasty.Journal of Knee Surgery. Mar 2015. PMID: 25699629
  • Lamplot J., Liu B., Zhang W., Wang Z., Luther G., Wagner E., He T.C., Ho S. Reversibly Immortalized Articular Chondrocytes Acquire Long-Term Proliferative Capability While Retaining Chondrogenic Phenotype.Cell Transplantation. Apr 2014. PMID: 24800751
  • Chen X., Luther G., Zhang W., Nan G., Wagner E., Liao Z., Haydon R., Zhou L., Luu H., He T.C. The E-F Hand Calcium-Binding Protein S100A4 Regulates the Proliferation, Survival and Differentiation of Potential of Human Osteosarcoma Cells.Cellular Physiology and Biochemistry. Sep 2013. PMID: 24217649
  • Hekman K., Aliaga L., Straus D., Luther G., Chen J., Sampat, Frim D. Positive and Negative Predictors for Good Outcome After Decompressive Surgery for Chiari Malformation Type 1 as Scored on the Chicago Chiari Outcome Scale.Neurological Research. Sep 2012. PMID: 22781921
  • Aliaga L., Yassari R., Straus D., Hekman K., Luther G., Chen J., Sampat A., Frim D. A Novel Scoring System for Assessing Chiari Malformation Type 1 Treatment Outcomes. Neurosurgery. Mar 2012 PMID: 21849925
  • Teven C., Liu X., Hu N., Tang N., Kim S., Huang E., Yang Ki., Li M., Gao J., Liu H., Luther G., Luo Q., Wang L., Rames R., Bi Y., Luo J., Luu H., Haydon R., Reid R., He T.C. Epigenetic Regulation of Mesenchymal Stem Cells: A Focus on Osteogenic and Adipogenic Differentiation. Stem Cells and Nuclear Reprogramming. Jul 2011. PMID: 21772852
  • Wagner E., Luther G., Zhu G., Luo G., Shi Q., Kim S., Gao J., Huang E., Gao Y., Yang K., Wang L., Teven C., Luo X., Liu X., Li M., Hu N., Su Y., Bi Y., He B.C., Haydon R., Luu H., He T.C. Defective Osteogenic Differentiation in the Development of Osteosarcoma.Sarcoma. Feb 2011. PMID: 21437219
  • Pandey S., Luther G., Umanskiy K., Malhotra G., Rubin M., Fichera A. Minimally Invasive Pouch Surgery for Ulcerative Colitis. Is there a Benefit in Staging?Disease of the Colon and Rectum. Feb 2011. PMID: 21304301
  • Rastegar F., Gao J., Shenaq D., Luo Q., Shi Q., Kim S., Jiang W., Wagner E., Huang E., Gao Y., Shen J., Yang K., He B.C., Chen L., Zuo G., Luo J., Luo X., Bi Y., Liu X., Li M., Nu N., Wang L., Luther G., Luu H., Haydon R., He T.C. Lysophosphatidic Acid Acyltransferase b (LPAATb) Promotes Tumor Growth of Human Osteosarcoma. PLoS ONE. Dec 2010. PMID: 21152068
  • He B.C., Gao J., Zhang B., Luo Q., Shi Q., Kim S., Huang E., Gao Y., Yang K., Wagner E., Wang L., Tang N., Luo J., Liu X., Li M., Bi., Shen J., Luther G., Hu N., Zhou Q., Luu H., Haydon R., Zhao Y., He T.C. Tetrandrine Inhibits Wnt/B-Catenin Signaling and Suppresses Tumor Growth of Human Colorectal Cancer.Molecular Pharmacology. Oct 2010. PMID: 20978119
  • Teply B., Tong R., Jeong S., Luther G., Sherifi I., Yim C., Khademhosseini A., Farokhzad O., Langer R., Cheng J. The Use of Charge-Coupled Polymeric Microparticles and Micromagnets for Modulating the Bioavailability of Orally Delivered Macromolecules.Biomaterials. Dec 2007. PMID: 18082254
  • Cheng J., Teply B., Sherifi I., Sung J., Luther G., Gu F., Nissenbaum E., Moreno A., Langer R., Farokhzad O. Formulation of Functionalized PLGA-PEG Nanoparticles for in Vivo Targeted Drug Delivery.Biomaterials. Feb 2007. PMID: 17055572